Publications by authors named "I L Campbell"
Background: The transition of young people with a disability or a chronic health condition, from paediatric to adult-focused health and social care services, in Scotland, is known to be difficult. There is a significant body of evidence to suggest that a transition should start early, be holistic and inclusive, as well as structured to build essential capabilities and promote resilience. The nurse-led project, reported here, created a playful mechanism for meaningful interaction between young people, families and healthcare professionals.
View Article and Find Full Text PDFPACIFIC-PGx evaluated the feasibility of implementing pharmacogenetics (PGx) screening in Australia and the impact of DPYD/UGT1A1 genotype-guided dosing on severe fluoropyrimidine (FP) and irinotecan-related toxicities and hospitalizations, compared to historical controls. This prospective single arm trial enrolled patients starting FP/irinotecan for any cancer between 7 January 2021 and 25 February 2022 from four Australian hospitals (one metropolitan, three regional). During the accrual period, 462/487 (95%) consecutive patients screened for eligibility for DPYD and 50/109 (46%) for UGT1A1 were enrolled and genotyped (feasibility analysis), with 276/462 (60%) for DPYD and 30/50 (60%) for UGT1A1 received FP/irinotecan (safety analysis).
View Article and Find Full Text PDFArticle Synopsis
- - The study examines how florigen and antiflorigen genes within the PEBP family influence flowering in angiosperms, especially in eelgrass, which is vital for its survival against climate change.
- - Researchers identified thirteen PEBP genes in eelgrass and found that four of them affect flowering when overexpressed; they analyzed gene expression using RT-PCR across different eelgrass populations and growth stages.
- - Results indicate that certain genes promote flowering while others inhibit it, with some genes expressed variably in different parts of the plant, suggesting a complex role in flowering and shoot architecture in eelgrass.
There is growing interest in road pollution that enters surface waters. Additive chemicals used in the manufacture of plastics, including tyre rubber, are mobile pollutants that pose a threat to aquatic life. Therefore, an ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed to measure 25 plastic additive chemicals in road runoff and water of retention ponds used to manage road runoff.
View Article and Find Full Text PDFObjectives: To describe longer-term survival and morbidity outcomes after hospital discharge in a binational cohort of children who required extracorporeal membrane oxygenation after cardiac surgery.
Methods: This was a retrospective cohort study from the Australia and New Zealand Congenital Outcomes Registry for Surgery database. All patients younger than 18 years of age (n = 12,290) undergoing pediatric cardiac surgical procedures between January 1, 2013, and December 31, 2021, who required post-cardiotomy extracorporeal membrane oxygenation in the same admission were included.