Publications by authors named "I Krishnan"
Aim: This study aimed to identify the imaging feature of perinephric myxoid pseudotumor of fat (PMPF) in a large cohort.
Materials And Methods: Institutional radiology and pathology databases were queried for PMPF for the period from January 2010 to December 2023. Of the 22 identified individuals, two were excluded due to nonavailability of computed tomography (CT) or magnetic resonance (MR) images and five due to lack of pathological confirmation.
Numerous challenges remain within conventional cell-based therapy despite the growing trend of stem cells used to treat various life-debilitating diseases. These limitations include batch-to-batch heterogeneity, induced alloreactivity, cell survival and integration, poor scalability, and high cost of treatment, thus hindering successful translation from lab to bedside. However, recent pioneering technology has enabled the isolation and enrichment of small extracellular vesicles (EVs), canonically known as exosomes.
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- Lung cancer, particularly lethal pulmonary adenocarcinomas, often shows mutations in the EGFR gene, making understanding tumor behavior and treatment important.
- Researchers utilized genetically engineered mice to study how tumors evolve and interact with their surrounding environment, identifying specific vulnerable cells and their communication with other cells in the tumor microenvironment.
- The drug Unesbulin, a tubulin binding agent, was found to decrease tumor growth and alter the interactions within the tumor environment, suggesting it could be a promising therapeutic strategy for treating EGFR-mutant lung cancers.
Background Total treatment time in implant placement can be significantly reduced by placing immediate implants into the freshly extracted sockets. Also, immediate implant placement can act as a guide for proper and accurate implant placement. Additionally, in immediate implant placement, the resorption of bone associated with the healing of the extraction socket is also reduced.
View Article and Find Full Text PDFLung cancer is the leading cause of cancer deaths. Tumor heterogeneity, which hampers development of targeted therapies, was herein deconvoluted via single cell RNA sequencing in aggressive human adenocarcinomas (carrying Kras-mutations) and comparable murine model. We identified a tumor-specific, mutant-KRAS-associated subpopulation which is conserved in both human and murine lung cancer.
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