Publications by authors named "I Krabbendam-Peters"
Article Synopsis
- Heart failure is becoming more common in older populations, and research suggests that DNA damage plays a key role in this condition.
- Scientists hypothesized that the ability to repair DNA in heart cells is crucial for maintaining heart function, and disrupting certain DNA repair genes (XPG and ERCC1) leads to severe heart problems and early death in mice.
- Analysis revealed that the lack of DNA repair causes increased oxidative stress, fibrosis, and apoptosis in heart tissue, pointing to DNA damage as a potential target for new treatments for heart failure.
Extensive application of coronary intravascular procedures has led to the increased need of understanding the injury inflicted to the coronary arterial wall. We aimed to investigate acute and prolonged coronary endothelial injury as a result of guidewire use, repeated intravascular imaging and stenting. These interventions were performed in swine (N = 37) and injury was assessed per coronary segment (n = 81) using an Evans Blue dye-exclusion-test.
View Article and Find Full Text PDFVariation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile: Findings From a Familial Hypercholesterolemia Pig Model.
Arterioscler Thromb Vasc Biol
November 2019
Article Synopsis
- The study examined coronary plaque development in adult pigs with familial hypercholesterolemia, revealing two distinct disease severities among the subjects.
- Advanced-diseased pigs developed human-like plaques with significant necrotic areas, while mildly diseased pigs only formed early lesions, despite having similar traditional risk factors.
- The research identified two subtypes of low-density lipoprotein (LDL) with varying lipid compositions, suggesting that differences in cholesterol and sphingolipid distribution in LDL may contribute to the severity of atherosclerosis in these pigs.
Pulmonary microvascular remodeling in chronic thrombo-embolic pulmonary hypertension.
Am J Physiol Lung Cell Mol Physiol
December 2018
Pulmonary vascular remodeling in pulmonary arterial hypertension involves perturbations in the nitric oxide (NO) and endothelin-1 (ET-1) pathways. However, the implications of pulmonary vascular remodeling and these pathways remain unclear in chronic thrombo-embolic pulmonary hypertension (CTEPH). The objective of the present study was to characterize changes in microvascular morphology and function, focussing on the ET-1 and NO pathways, in a CTEPH swine model.
View Article and Find Full Text PDFBackground: DM remains a risk factor for poor outcome after stent-implantation, but little is known if and how DM affects the vascular response to BVS.
Aim: The aim of our study was to examine coronary responses to bioresorbable vascular scaffolds (BVS) in swine with and without diabetes mellitus fed a 'fast-food' diet (FF-DM and FF-NDM, respectively) by sequential optical coherence tomography (OCT)-imaging and histology.
Methods: Fifteen male swine were evaluated.