Excision of a part of the bile duct as an iatrogenic injury typical for laparoscopic cholecystectomy - characteristics, treatment and long-term results, based on own material.

Introduction: Cholecystectomy is associated with the risk of bile duct injury (BDI). The nature of the injury in laparoscopic cholecystectomy (LC) cases seems to be more serious.

Aim: We present an analysis of long-term results of the treatment of patients who underwent operations at our department due to iatrogenic excision of a part of the bile duct (EPBD).

Phosducin regulates secretory activity in TT line of thyroid parafollicular C cells.

The endocrine activity of the thyroid gland is accomplished by its follicular and parafollicular cells. In these cells, numerous G proteins-dependent pathways are active and potentially could be regulated by a 33-kDa cytoplasmic protein phosducin, which interacts with the Gβ subunit and may compete with Gα or Gβγ dimer effectors. Significant expression of phosducin has been shown in the retina, pineal gland, and some neurons.

Diverse β subunits of heterotrimeric G proteins are present in thyroid plasma membranes.

The functioning of heterotrimeric G protein α subunits in the transduction of hormonal signals to appropriate intracellular responses is well recognized. Much less is known about the distribution of isoforms and functions of G protein β subunits. Here, using specific antibodies, we documented that in plasma membranes of the thyroid cell line Nthy-ori 3-1 all Gβ isoforms-Gβ(1), Gβ(2), Gβ(3), Gβ(4) and Gβ(5) are present, while the Gβ(3) occurs in minute amount.

[Epithelioma calcificans malherbe].

Authors described the case of familial occurrence of epithelioma calcificans Malherbe (pilomatricoma) in 6-year-old boy and his 68-year-old grandfather. Tumors were clinically diagnosed as atheromas of nucha and shoulder.

[Anastomosis of ducts and intestines in non-neoplastic bile duct stricture].

Recurrence of hepaticojejunal anastomotic stricture should be regarded as an operative risk, particularly in the case of patients with type III and IV stricture according to Bismuth classification. This complication should be taken into account, especially in the first five postoperative years. Since in some cases, biliary stricture has an insidious course with nebulous clinical symptoms.