Publications by authors named "I Kouassi Yao"
Interpolation of Imaging Mass Spectrometry Data by a Window-Based Adversarial Autoencoder Method.
J Am Soc Mass Spectrom
January 2025
Article Synopsis
- Imaging mass spectrometry (IMS) is essential for studying the distribution of molecules in samples, but handling large data sets can be time-consuming and resource-intensive.
- This study introduced a high-resolution reconstruction technique using a window-based Adversarial Autoencoder (AAE) to improve the analysis of IMS data from mouse cerebellum and kidney tissues.
- The AAE model outperformed traditional interpolation methods (Bilinear and Bicubic) in image quality, making it a promising tool for large-scale IMS research in animal organ studies.
There are various forms of stress including; physical, psychological and social stress. Exposure to physical stress can lead to physical sensations (e.g.
View Article and Find Full Text PDFMatrix-assisted laser desorption/ionization imaging mass spectrometry (IMS) is used to comprehensively visualize the spatial distribution of numerous biomolecules. The present study was designed to investigate the distribution of phospholipids in developing rat teeth by IMS to identify the characteristic phospholipid molecules for tooth development, and to evaluate the suitability of tissue preparation methods. Rats at postnatal day 3 were euthanized, and the resected head specimens were either fixed or not fixed with 4% paraformaldehyde (PFA), and decalcified or not decalcified in 10% ethylenediaminetetraacetic acid (EDTA) before being frozen.
View Article and Find Full Text PDFArticle Synopsis
- Brain function depends on quick electrical communication between neurons and synchrony of neural activity, with myelin sheaths playing a crucial role in this process.
- The study explored how myelin lipid composition changes during different stages of motor learning in mice, finding that sphingomyelin increases early on, while galactosylceramide levels rise later on.
- Inhibiting galactosylceramide synthesis related to myelin affects motor learning, indicating that adjustments in myelin lipid composition are important for effective learning processes.
Article Synopsis
- Glutamate is a key neurotransmitter present in over 90% of excitatory synapses in the human brain, but its metabolic pathways are complex and not completely understood.
- The study focuses on two proteins, TTLL1 and TTLL7, responsible for tubulin polyglutamylation in the brain, which is linked to maintaining neuronal polarity.
- Researchers created knockout mice for these proteins and discovered abnormal behaviors linked to increased glutamate levels in their brains, indicating that tubulin polyglutamylation may regulate glutamate and other amino acids in neurons.