Publications by authors named "I Koscinski"
The COVID-19 pandemic, driven by SARS-CoV-2, led authorities to recommend halting assisted reproductive technology programs, focusing instead on fertility preservation, for cancer patients. The presence of SARS-CoV-2 in semen remains controversial. This multicentric prospective cohort study, conducted across 12 university medical centers, aimed to determine if SARS-CoV-2 is present in spermatozoa/seminal plasma in cancer patients by RT-PCR and to assess its impact on standard semen parameters.
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- The study investigates the link between parental occupational exposure to solvents and the risk of testicular germ cell tumors (TGCT) in their sons, focusing on environmental risk factors during pregnancy.
- The research involved a nationwide case-control study in France with 454 TGCT cases and 670 controls, assessing parental job exposure to various solvents through structured interviews and job-exposure matrices.
- Findings indicated a slight increase in TGCT risk associated with paternal exposure to certain solvents, particularly trichloroethylene, and a higher risk for men born in the 1970s with maternal exposure to fuels, but overall no strong connection between solvent exposure and TGCT was established.
Endometriosis is a chronic disease caused by ectopic endometrial tissue. Endometriotic implants induce inflammation, leading to chronic pain and impaired fertility. Characterized by their dependence on estradiol (via estrogen receptor β (ESRβ)) and their resistance to progesterone, endometriotic implants produce their own source of estradiol through active aromatase.
View Article and Find Full Text PDFMale factors are suspected in around half cases of infertility, of which up to 40% are diagnosed as idiopathic. In the context of a continuously increased resort to ART and increased decline of semen parameters, it is of greatest interest to evaluate an additional potential biomarker of sperm quality. According to PRISMA guidelines, this systematic review of the literature selected studies evaluating telomere length in sperm and/or in leukocytes as a potential male fertility biomarker.
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