Publications by authors named "I Koralnik"
Article Synopsis
- The study explores the neurological effects of SARS-CoV-2 infection in two groups: post-hospitalized patients (PNP) and non-hospitalized patients (NNP), across different age ranges.
- It analyzed data from 200 PNP and 1,100 NNP patients evaluated at a specialized clinic between May 2020 and March 2023, focusing on how age influences neurological symptoms and quality of life.
- Findings showed that younger adults had higher reported fatigue, sleep disturbances, and poorer executive function compared to older individuals, who exhibited a lower prevalence of Neuro-PASC symptoms despite having more comorbidities.
Long COVID, also called post-acute sequelae of SARS-CoV-2 infection (PASC) affects millions of people in the world. The neurologic manifestations of PASC (Neuro-PASC) are among the most debilitating but they are largely unreported in Africa. We sought to compare the demographics, symptoms and cognitive profile of post-hospitalization Neuro-PASC (PNP) and non-hospitalized Neuro-PASC (NNP) patients in Nigeria.
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- - The study focused on the impact of an evidence-based sedation bundle for ICU patients requiring mechanical ventilation during the early phase of the COVID-19 pandemic, addressing the challenges posed by increased patient volumes.
- - Researchers implemented the sedation bundle using structured training and feedback, aiming to encourage goal-directed sedation to prevent excessive use of sedatives among critically ill COVID-19 patients.
- - A comparison of sedative use and clinical outcomes was made between patients admitted before and after the bundle implementation, revealing increased use of benzodiazepines and changes in patient care metrics.
Neurologic manifestations of Long COVID in Colombia: a comparative analysis of post-hospitalization vs. non-hospitalized patients.
Carolina Hurtado Diego Fernando Rojas-Gualdrón Gina S Pérez Giraldo Esteban Villegas Arbelaez Salvador Ernesto Medina Mantilla Igor J Koralnik
Front Hum Neurosci
August 2024
Article Synopsis
- The study aimed to evaluate the long-term effects of COVID-19 on neurological symptoms, cognitive function, and quality of life in Colombian patients experiencing neurological post-acute sequelae (Neuro-PASC).
- Researchers analyzed data from 100 patients (50 post-hospitalization and 50 non-hospitalized) who had persistent symptoms for over 6 weeks, highlighting common symptoms like brain fog, fatigue, and anxiety.
- Results indicated that both groups had impaired quality of life and cognitive function, with recommendations for early detection and support for Neuro-PASC patients to address these ongoing challenges.
Article Synopsis
- Mild SARS-CoV-2 infections can lead to an increase in autoantibodies linked to autoimmune diseases, regardless of whether the individual was vaccinated before infection.
- Patients suffering from long COVID, especially those with ongoing neurological issues, show significantly higher levels of autoantibodies compared to those who have recovered without these symptoms.
- The findings suggest a need to reconsider current strategies for preventing SARS-CoV-2 transmission to mitigate the risk of developing autoimmune conditions.