Publications by authors named "I Kolarova"
The role of postmastectomy radiotherapy and regional nodal irradiation after radical mastectomy is defined in high-risk patients with locally advanced tumors, positive margins, and unfavorable biology. The benefit of postmastectomy radiotherapy in intermediate-risk patients (T3N0 tumors) remains a matter of controversy. It has been demonstrated that radiotherapy after breast-conserving surgery lowers the locoregional recurrence rate compared with surgery alone and improves the overall survival rate.
View Article and Find Full Text PDFPurpose: Male breast cancer (MBC) is a rare, but increasingly common disease, and lacks prospective studies. Collaborative efforts are needed to understand and address MBC, including its prognosis, in different countries.
Methods: We retrospectively reviewed the clinical, histopathological, and molecular-genetic characteristics, treatments, and survival outcomes of MBC diagnosed between 2007 and 2017 in the Czech Republic.
spp. (Kinetoplastida) are unicellular parasites causing leishmaniases, neglected tropical diseases of medical and veterinary importance. In the vertebrate host, parasites multiply intracellularly in professional phagocytes, such as monocytes and macrophages.
View Article and Find Full Text PDFArticle Synopsis
- - Modern radiotherapy techniques aim to minimize radiation exposure to healthy tissues, leading to fewer side effects and faster recovery times for patients.
- - Randomized studies show that increasing the radiation dose specifically to the tumor area during whole breast irradiation (WBI) can enhance treatment effectiveness, reducing the traditional treatment time from 5-7 weeks to just 3-4 weeks with hyperfractionated regimens.
- - Accelerated partial breast irradiation (APBI) allows for a shorter treatment timeline and less radiation to healthy tissue, using methods like intraoperative radiation, brachytherapy, or external beam radiotherapy, while still achieving acceptable cosmetic results, especially in patients undergoing immediate breast reconstruction.
Article Synopsis
- Parasitic protists are responsible for major diseases affecting both humans and animals, including malaria and toxoplasmosis.
- These diseases can have severe health impacts, leading to serious illness or death.
- Understanding these organisms is crucial for prevention and treatment strategies in public health.