Publications by authors named "I Koizuka"

Ménière's disease (MD) is characterized by loss of balance and hearing disorders. Although there is known to be endolymphatic hydrops involved in the pathological process, the pathogenesis of the disease is still largely unclear. Approximately half of patients with MD suffer from depressive symptoms and high levels of several stress hormones were observed in MD and depression, simultaneously.

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The persistent stapedial artery (PSA) is an exceedingly vascular anomaly that can lead to hearing loss or pulsatile tinnitus, yet its preoperative diagnosis is often challenging. We report the case of a 24-year-old woman with bilateral PSA and stapes ankylosis who presented with progressive bilateral mixed hearing loss. The patient was initially diagnosed with bilateral congenital stapes ankylosis and stapes surgery was performed on the left side using transcanal endoscopic ear surgery (TEES).

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A perilymphatic fistula (PLF) presents with abnormal traffic in the otic capsule, causing cochlear and vestibular symptoms. However, the mechanisms underlying symptom recurrence remain controversial. Herein, we report the case of a 27-year-old female who complained of hearing disturbance in her right ear and recurrent vertigo after sudden onset of hearing loss with vertigo.

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Article Synopsis
  • The study investigated the effects of high-dose betahistine (72 mg/day) on dizziness in patients with unilateral vestibulopathy, contrasting it with a standard dose (36 mg/day).
  • Fifteen patients suffering from chronic dizziness participated, and results showed that the high-dose significantly reduced their dizziness handicap inventory (DHI) scores, particularly in six patients.
  • The findings suggest that while the standard dose was ineffective, long-term high-dose treatment may aid vestibular compensation and improve symptoms in some patients with severe dizziness.
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Article Synopsis
  • The objective of the study was to outline diagnostic and treatment strategies for vestibular neuritis based on the 2021 Japanese Clinical Practice Guidelines.
  • A committee reviewed scientific literature and created clinical questions to guide the treatment recommendations, leveraging both research findings and expert opinions.
  • The results included established diagnostic criteria and tailored treatment approaches for vestibular neuritis at various stages (acute, subacute, chronic), emphasizing the guidelines as a key resource for practitioners.
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