Publications by authors named "I Kockum"
The potential of ancient DNA analyses to provide independent sources of information about events in the historical record remains to be demonstrated. Here we apply palaeogenomic analysis to human remains excavated from a medieval well at the ruins of Sverresborg Castle in central Norway. In , the Old Norse of King Sverre Sigurdsson, one passage details a 1197-CE raid on the castle and mentions a dead man thrown into the well.
View Article and Find Full Text PDFBackground: Women have a higher risk of developing multiple sclerosis (MS), potentially due to hormonal factors. Elevated testosterone levels, common in polycystic ovary syndrome (PCOS), might influence MS risk.
Objective: To investigate the relationship between PCOS, as a proxy for elevated testosterone levels, and MS risk through phenotypic and genomic analysis.
Background: Inter-individual differences in treatment response are marked in multiple sclerosis (MS). This is true for Natalizumab (NTZ), to which a subset of patients displays sub-optimal treatment response. We conducted a multi-centric genome-wide association study (GWAS), with additional pathway and network analysis to identify genetic predictors of response to NTZ.
View Article and Find Full Text PDFGenetic association of antinuclear antibodies with HLA in JIA patients: a Swedish cohort study.
Pediatr Rheumatol Online J
August 2024
Background: Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disease and the most common chronic rheumatological disease affecting children under the age of 16. The etiology of JIA remains poorly understood, but evidence suggests a significant genetic predisposition.
Methods: We analyzed a Swedish cohort of 329 JIA patients and 728 healthy adult controls using the Illumina OmniExpress array for genotyping.
Article Synopsis
- The study investigates the familial connection between multiple sclerosis (MS) and immune mediated inflammatory diseases (IMIDs), given that even though MS is rare, IMIDs are more common and can impact public health.* -
- Researchers analyzed data from almost 25,000 MS patients and over 250,000 controls, looking specifically at the odds of developing MS in individuals with first-degree relatives who have IMIDs.* -
- Findings showed a slight increase in risk (OR of 1.09) for MS in families with a history of IMIDs and identified 18 IMID subtypes that are associated with MS, indicating potential shared genetic factors.*