Publications by authors named "I Knudsen"

The microbiological analysis of wastewater samples is increasingly used for the surveillance of SARS-CoV-2 globally. We described the setup process of the national SARS-CoV-2 wastewater-based surveillance system in Denmark, presented its main results during the first year of activities, from July 2021 to June 2022, and discussed their operational significance. The Danish SARS-CoV-2 wastewater-based surveillance system was designed to cover 85 % of the population in Denmark and it entailed taking three weekly samples from 230 sites.

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  • Candidemia is a serious fungal infection linked to high mortality rates, emphasizing the need for prompt diagnosis through blood cultures, especially since fungi are often overlooked in standard sepsis treatments.
  • A study compared blood culture results from 2018 and 2020 in Denmark, noting a significant improvement in identifying fungi when a mycosis flask was added to blood culture sets, especially in high-risk patient areas.
  • The research found that including a mycosis flask increased the likelihood of detecting candidemia, with a notable difference in high-risk departments, suggesting a need for tailored blood culture strategies in those settings.
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Background: Staphylococcus aureus bacteremia (SAB) is frequently encountered in the hospital setting, and current guidelines recommend at least 14 days of antibiotic treatment for SAB in order to minimize risks of secondary deep infections and relapse. However, evidence to support these treatment recommendations remains scarce. Patients with uncomplicated SAB are known to have a low of risk of recurrence and death.

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Four new α-glucosidase inhibitors have been synthesised through 5-8 synthetic steps from a common synthetic intermediate obtained through a recently developed carbocyclisation. The compounds were designed as hybrids of the known glucosidase inhibitors valienamine, voglibose and miglitol. All four compounds showed activity against rat intestinal sucrase with the most potent inhibitor acting at low micromolar concentration.

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  • The study looked at how doing physically hard work, like lifting heavy things, during pregnancy could increase the chance of having a baby early.
  • Researchers checked the information from 343 pregnant women and compared it to a much larger group of working women.
  • They found that women who lifted heavy loads had babies about 2.4 days earlier than others, suggesting that it might be riskier for them during pregnancy.
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