Secretion of basal gonadotropins after LRH decapeptide and tripeptide. Stimulation in hypogonadotropic hypogonadism.

Sixteen females with pubertary delay of the isolated hypogonadotropic hypogonadism type (mean age 19 years, age range 14-25 years) were studied by radioimmunoassay of LH and FSH. The mean values +/- SE were compared to the values obtained from 10 girls in the B 5 Tanner stage and 15 normal adult women investigated on the 14th and 21st day of their ovarian cycle. Two females were given the LRH decapeptide and LRH-LA tripeptide stimulation test.

Pituitary function in 20 cases of prolactinoma in females.

Women with prolactinic pituitary tumor in the fertile period have increased (60-400 ng/ml) blood prolactin values and decreased LH and FSH as compared to healthy women of the same age. Among the mechanisms implied in prolactin hypersecretion in females with prolactinic tumor worth noting are: low receptivity to dopamine, low dopamine production, elevated serotonin and TRH production, stress factors. Suppression of prolactin secretion with bromcriptine induces a rise in LRH and consequently in LH and FSH.

Receptivity disorders in gonadal dysgeneses. i. Klinefelter's syndrome.

Long-term variation (21-30 days) in the gonadotropic hormones level and testosterone was followed up in Klinefelter's syndrome (chromatine positive). Clinically, the authors followed up the development of the androgen-dependent target tissues before and after administration of 400 mg testosterone/month for 6 months. It was also found a fluctuation in the gonadotropic hormones secretion on a 21-30-day trial which differs from that of the normal adult male.

Clinical and hormonal effects of testosterone undecanoate (TU) in male sexual impotence.

Eight patients with sexual impotence, fertile and clinically normal, average age of 41, were given TU orally for 46 days, in a dose of 120 mg/day. The mean (+/- SE) plasma FSH, LH and testosterone levels were significantly lower than in a group of 20 healthy adult men, average age 36. In the course of treatment there were no significant changes of mean serum FSH and LH concentrations, while circulating testosterone levels rose significantly to normal levels throughout the whole study.