In silico dissection of cell-type-associated patterns of gene expression in prostate cancer.

Prostate tumors are complex entities composed of malignant cells mixed and interacting with nonmalignant cells. However, molecular analyses by standard gene expression profiling are limited because spatial information and nontumor cell types are lost in sample preparation. We scored 88 prostate specimens for relative content of tumor, benign hyperplastic epithelium, stroma, and dilated cystic glands.

Use of keyword hierarchies to interpret gene expression patterns.

Motivation: High-density microarray technology permits the quantitative and simultaneous monitoring of thousands of genes. The interpretation challenge is to extract relevant information from this large amount of data. A growing variety of statistical analysis approaches are available to identify clusters of genes that share common expression characteristics, but provide no information regarding the biological similarities of genes within clusters.

[Primary ciliary dyskinesia--importance of early diagnosis].

Background: Primary ciliary dyskinesia (PCD) is an inherited disease characterized by specific ultrastructural defects of cilia and sperms. The impairment of mucociliary clearance (MCC) results in chronic respiratory infections and subsequently in bronchiectasis.

Main Purpose: The evaluate rational decisions in early diagnosis of PCD.

Modulation of humoral and cellular resistance in children with laryngeal papillomatosis.

As accessory cells in immunity response immunoglobulin and lymphocytes participate in antitumor immunity. Quantitative changes in concentrations and numbers were studied once before therapy, without examining the functional state. In order to gain more information on the humoral response during and after treatment, and in cases of recurrence, bactericidal antibodies against B.

[The role of Toxoplasma gondii in the etiology of chronic tonsillitis in children].

Toxoplasma gondii is know to have an affinity to lymphatic tissue. The authors studied whether after infection of the child's body T. gondii does or does not determine the chronic course of tonsillitis.