Model-based calculation of thyroid gland normal tissue complication probability in head and neck cancer patients after radiation therapy.

Aim: Primary hypothyroidism is one of the late complications that can occur after radiation therapy for malignant tumors in the head and neck region. The aim of this retrospective study was to show the validity of the Lyman-Kutcher-Burman (LKB) normal tissue complication model for thyroid gland based on clinical results.

Methods: Thyroid function was evaluated by measuring thyroid-stimulating hormone and free thyroxine serum levels before radiation therapy, 3 months after the beginning of radiation therapy, and afterwards at each follow-up visit.

Long-term alterations of cell population in the adult rat forebrain following the exposure to fractionated doses of ionizing radiation.

We investigated radiation-induced delayed alterations of proliferating population, cells undergoing apoptosis and glial cells housed rat brain neurogenic region. Adult male Wistar rats were investigated 30, 60 or 90 days after whole-body irradiation with fractionated doses of gamma rays (the total dose of 4 Gy). Using immunohistochemistry for detection of cell proliferation marker Ki-67, caspase3 as apoptotic marker and GFAP for mature astrocytes we have been performed quantitative analysis in different forebrain's areas along the SVZ-OB axis, i.

[Thyroid disorders in women with breast cancer].

Aim: Increasing prevalence of non-malignant thyroid disorders in women with breast cancer has been known for several decades; it is said to be associated with a better prognosis of the cancerous disease. The aim of this work was to analyse associations between thyropathies found in women with breast cancer and particular prognostic factors.

Patients And Methods: A group of 110 women with breast cancer were tested for autoimmune thyroiditis (AIT) and functional changes of the thyroid gland.

Radiation-induced long-term alterations in hippocampus under experimental conditions.

Backgrounds: The aim of the present study was to investigate the effect of ionizing radiation on the cell population that co-forms hippocampal formation in an adult rat brain.

Materials And Methods: Adult male Wistar rats were exposed to whole-body irradiation with fractionated doses of gamma rays (the total dose of 4 Gy). Thirty, 60 and 90 days after irradiation the cell-specific types housed in the CA1, CA3 subregions and adjacent layers were labelled using immunohistochemistry for specific cell phenotypes; Ki-67 marker was used for proliferating cells and GFAP for detection of astrocytes.

[Low-dose radiotherapy in the treatment of plantar fasciitis].

Backgrounds: To evaluate the analgesic effect of low-dose radiotherapy in the treatment of plantar fasciitis and to analyse prognostic factors.

Patients And Methods: Retrospective analysis was used in the assessment of the analgesic effect after the 1st and 2nd series of low-dose radiotherapy. The treatment regime of 273 patients included total dose of 4.