Oncoprotein 18 is necessary for malignant cell proliferation in bladder cancer cells and serves as a G3-specific non-invasive diagnostic marker candidate in urinary RNA.

Background: Urine-based diagnostics indicated involvement of oncoprotein 18 (OP18) in bladder cancer. In cell culture models we investigated the role of OP18 for malignant cell growth.

Methods: We analyzed 113 urine samples and investigated two human BCa cell lines as a dual model: RT-4 and ECV-304, which represented differentiated (G1) and poorly differentiated (G3) BCa.

Destruction of stone extraction basket during an in vitro lithotripsy--a comparison of four lithotripters.

Background: Various techniques are available for intracorporeal disintegration of renal and ureteral stones, among them ballistic lithotripsy, ultrasonic lithotripsy and laser lithotripsy. The therapeutic effectiveness of these devices has been sufficiently studied and compared. This does not apply, however, to the risk of destroying the stone basket.

mTOR inhibitors show promising in vitro activity in bladder cancer and head and neck squamous cell carcinoma.

Bladder cancer and head and neck squamous cell carcinoma (HNSCC) are frequent but lack efficient therapies especially in advanced disease. Almost no studies on mTOR function and inhibition in these tumor entities have been reported. We examined the gene and protein expression levels of mTOR and its activated form (pmTOR) in three human bladder carcinoma cell lines (RT-4, T24, EJ28) and three HNSCC cell lines (PCI-1, PCI-13, BHY).

[Endourological lithotripsy for stone removal: accidental fragmentation of dormia basket and guidewire - a brief overview].

Endoscopic lithotripsy of stones is one of the most frequently performed procedures in urology. Sometimes dormia baskets and guidewire will be fragmented accidentally by the laser (Hol:YAG), by ultrasound, or by mechanical lithotripsy (electromechanical or pneumatic).A search for articles on this subject was performed.

[Quality of life after radical cystectomy - an overview and analysis of a contemporary series].

Objective: Published evidence does not support a clear advantage in quality of life for continent versus incontinent urinary diversion or vice versa.

Patients And Methods: We retrospectively assessed 61 patients after radical cystectomy with the EORTC-QLQ-C30 and -BLM30 instruments. Analysis was performed in dependence of age, sex, technique of urinary diversion and time-course of therapy.