Publications by authors named "I Kati Loeffler"
Article Synopsis
- - The study focuses on understanding the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) in patients with hemolytic-uremic syndrome (HUS), where up to 40% experience long-term health issues.
- - Researchers created a long-term mouse model using Shiga toxin (Stx) to observe disease progression and identify key time points for AKI transitioning into CKD symptoms.
- - Results showed a shift from acute symptoms to chronic changes, including increased interstitial fibrosis and a predominance of pro-fibrotic macrophages, which could help in developing treatments to prevent CKD in affected patients.
Article Synopsis
- The study investigates the role of non-fibrillar collagen type VIII (COL8) in kidney aging and fibrosis in a mouse model.
- It finds that COL8 expression is influenced by age and sex, affecting the development of kidney damage and function.
- The research highlights the complex relationship between COL8 and renal health, suggesting that targeting COL8 could be important for understanding age-related kidney issues.
Epigenetic alterations contribute to the pathogenesis of chronic diseases such as diabetes mellitus. Previous studies of our group showed that diabetic conditions reduce the trimethylation of H3K27 in podocytes in a NIPP1- (nuclear inhibitor of protein phosphatase 1) and EZH2- (enhancer of zeste homolog 2) dependent manner. It has been previously reported that in differentiated podocytes, hypoxia decreases the expression of slit diaphragm proteins and promotes foot process effacement, thereby contributing to the progression of renal disease.
View Article and Find Full Text PDFThe mitogen-activated protein kinase organizer 1 (MORG1) is a scaffold molecule for the ERK signaling pathway, but also binds to prolyl-hydroxylase 3 and modulates HIFα expression. To obtain further insight into the role of MORG1, knockout-mice were generated by homologous recombination. While Morg1+/- mice developed normally without any apparent phenotype, there were no live-born Morg1-/- knockout offspring, indicating embryonic lethality.
View Article and Find Full Text PDFDifferences between the sexes exist in many diseases, and in most cases, being a specific sex is considered a risk factor in the development and/or progression. This is not quite so clear in diabetic kidney disease (DKD), the development and severity of which depends on many general factors, such as the duration of diabetes mellitus, glycemic control, and biological risk factors. Similarly, sex-specific factors, such as puberty or andro-/menopause, also determine the microvascular complications in both the male and female sex.
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