Publications by authors named "I Katayama"
Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, endogenous HHV-6 (eHHV-6) and anellovirus.
View Article and Find Full Text PDFIn order to examine the rock dependence on drilling performance parameters, such as torque and rate of penetration (ROP), we conducted laboratory drilling experiments using mafic and ultramafic rocks from the Oman ophiolite and the Horoman Complex. Serpentinized peridotite shows approximately twice the ROP (dry conditions: 2.95 ~ 3.
View Article and Find Full Text PDFArticle Synopsis
- Prurigo chronica multiformis is a specific type of skin condition primarily recognized in Japan, especially among elderly patients, characterized by extremely itchy, swollen patches on the skin.
- The lesions evolve from small, itchy bumps to more solid nodules that might group together, often appearing on areas like the lower abdomen and lower back.
- There is a need for more research on its incidence, variations based on geography, and how it relates to other skin diseases, and dermatologists should be informed about its unique clinical features.
The basement membrane zone is the interface between the epidermis and dermis, and it is disrupted in several skin conditions. Here, we report the results of a comprehensive investigation into the structural and molecular factors of the basement membrane zone in vitiligo, a dermatological disorder characterised by depigmented patches on the skin. Using electron microscopy and immunofluorescence staining, we confirmed abnormal basement membrane zone morphology and disrupted basement membrane zone architecture in human vitiliginous skin.
View Article and Find Full Text PDFEpidermal melanin unit integrity is crucial for skin homeostasis and pigmentation. Epidermal growth factor (EGF) receptor (EGFR) is a pivotal player in cell growth, wound healing, and maintaining skin homeostasis. However, its influence on skin pigmentation is relatively unexplored.
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