The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer.

Adipogenesis associated Mth938 domain containing (AAMDC) represents an uncharacterized oncogene amplified in aggressive estrogen receptor-positive breast cancers. We uncover that AAMDC regulates the expression of several metabolic enzymes involved in the one-carbon folate and methionine cycles, and lipid metabolism. We show that AAMDC controls PI3K-AKT-mTOR signaling, regulating the translation of ATF4 and MYC and modulating the transcriptional activity of AAMDC-dependent promoters.

Genomic findings in patients with clinical suspicion of 22q11.2 deletion syndrome.

Chromosome 22q11.2 deletion syndrome, one of the most common human genomic syndromes, has highly heterogeneous clinical presentation. Patients usually harbor a 1.

[Chitosan-alginate biocomposites in the form of films used in bedsores treatment].

During recent years here has been a growing interest in developing dressing materials that would provide protection and more effective treatment of bedsores in different phases of healing and at the same time would play a role as a carrier of active substances. Dressings of this type should be made of special biodegradable polymeric materials which are good promoters of absorption of the active substances and characterized by good sorption properties. The paper presents preliminary studies related to the development composite films produced on the basis of biopolymers--chitosan and sodium alginate, with the participation of anti-inflammatory product.

A girl with duplication 9q34 syndrome.

We report on a 17-year-old female with numerous developmental abnormalities associated with 46,XX,dup(9)(q33.3q34.1), where the duplication occurred de novo.