Publications by authors named "I Kalliala"
Background: Amplicon sequencing of kingdom-specific tags such as 16S rRNA gene for bacteria and internal transcribed spacer (ITS) region for fungi are widely used for investigating microbial communities. So far most human studies have focused on bacteria while studies on host-associated fungi in health and disease have only recently started to accumulate. To enable cost-effective parallel analysis of bacterial and fungal communities in human and environmental samples, we developed a method where 16S rRNA gene and ITS1 amplicons were pooled together for a single Illumina MiSeq or HiSeq run and analysed after primer-based segregation.
View Article and Find Full Text PDFObjectives: We studied the short- and long-term effects of imatinib in hospitalized COVID-19 patients.
Methods: Participants were randomized to receive standard of care (SoC) or SoC with imatinib. Imatinib dosage was 400 mg daily until discharge (max 14 days).
Background: Peripartum asphyxia is one of the main causes of neonatal morbidity and mortality. In moderate and severe cases of asphyxia, a condition called hypoxic-ischemic encephalopathy (HIE) and associated permanent neurological morbidities may follow. Due to the multifactorial etiology of asphyxia, it may be difficult prevent, but in term neonates, therapeutic cooling can be used to prevent or reduce permanent brain damage.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the cost-effectiveness of various treatments for cervical intraepithelial neoplasia (CIN) in women in England.
- A decision-analytic model simulated the outcomes for 1,000 women receiving local treatment for CIN over a 10-year follow-up, considering surgical complications and related costs to the NHS.
- Results indicated that large loop excision of the transformation zone (LLETZ) was the most cost-effective treatment for both younger and older women, with laser conisation becoming more viable for older women if costs were above £31,500 per recurrence averted.
Objective: This study aimed to provide procedure-specific estimates of the risk for symptomatic venous thromboembolism and major bleeding in noncancer gynecologic surgeries.
Data Sources: We conducted comprehensive searches on Embase, MEDLINE, Web of Science, and Google Scholar. Furthermore, we performed separate searches for randomized trials that addressed the effects of thromboprophylaxis.