Publications by authors named "I Kadas"
Article Synopsis
- A series of synthesized derivatives of (±)-trans-dihydronarciclasine and (±)-trans-dihydrolycoricidine, focusing on variations in ring A, were tested against 60 human tumor cell lines to evaluate their anti-cancer effects.
- Among the 13 tested alkaloids, (±)-trans-dihydronarciclasine demonstrated the strongest ability to kill cancer cells.
- A structure-activity relationship analysis revealed that a hydroxy group at position 7 and a rigid 1,3-benzodioxole structure are crucial for the antiproliferative effectiveness of these compounds.
Abstract: Some new -dihydronarciclasine derivatives containing a 1,4-benzodioxane moiety were stereoselectively synthesised using our feasible and efficient method developed recently. These new phenanthridone alkaloid analogues were obtained in both racemic and optically active forms. High enantioselectivities (up to 99% ) were achieved by applying (8,9)-9-amino(9-deoxy)epiquinine as an organocatalyst.
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- A new method for synthesizing the biologically active alkaloid (-)-trans-dihydronarciclasine was developed starting from vanillin.
- The synthesis features a key step involving an asymmetric, organocatalytic Michael addition that produces an optically active nitropentanone with over 99% enantioselectivity.
- The process is efficient, achieving the target molecule in 13 steps and providing access to a form of a potent cytostatic alkaloid that was previously difficult to obtain.
The developing callus requires sufficient oxygen and substrate supply. Despite the importance of these processes, we have limited understanding of regulation of the callus microcirculation. We aimed to assess the role of vasoactive substances in the microcirculation of the callus in a gap osteotomy model in the rabbit detected by laser-Doppler flowmetry.
View Article and Find Full Text PDFDifferent bones have different blood supplies, which may influence bone healing. Therefore, elucidation of the mechanisms involved in the regulation of bone marrow blood flow in different bones is of high clinical importance. To assess the micro circulation of bone marrow of the femur and tibia simultaneously, flow velocities were continuously measured by a two-channel laser-Doppler flowmeter.
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