Resazurin dye is an in vivo sensor of kidney tubular function.

Glomerular filtration rate (GFR) is the main functional index of kidney health and disease. Currently, no methods are available to directly measure tubular mass and function. Here, we report a serendipitous finding that the in vitro cell viability dye resazurin can be used in mice as an exogenous sensor of tubular function.

Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury.

Transcriptional profiling studies have identified several protective genes upregulated in tubular epithelial cells during acute kidney injury (AKI). Identifying upstream transcriptional regulators could lead to the development of therapeutic strategies augmenting the repair processes. SOX9 is a transcription factor controlling cell-fate during embryonic development and adult tissue homeostasis in multiple organs including the kidneys.

Functional magnetic resonance imaging following epimacular and internal limiting membrane peeling - ipsilateral and contralateral findings.

Purpose: The purpose of this study was to find out whether peeling of the epimacular membrane (EMM) and internal limiting membrane (ILM) for symptomatic lamellar macular hole (LMH), causes impairment of the visual cortex.

Patients And Methods: This pilot study consisted of 8 eyes of 4 patients (2 females and 2 males), mean age 69.25 years (60-83 years), who underwent pars plana vitrectomy and EMM and ILM peeling in one eye for lamellar macular hole The second eye remained intact.

Functional Magnetic Resonance Imaging in Patients with the Wet Form of Age-Related Macular Degeneration.

The study is designed to determine the relationship between the progress of the wet form of age-related macular degeneration and the activity of the visual cortex examined using functional magnetic resonance imaging. Ten patients with the wet form of age-related macular degeneration (9 female and 1 male) with a mean age of 74.7 years (58-85 years) at various stages of bilateral involvement of the disease were included.

Optical coherence tomography in progressive cone dystrophy.

Aim: The aim of the study was to analyse different clinical pictures in patients with progressive cone dystrophy (PCD), to compare these with the results of optical coherence tomography (OCT) and to evaluate the benefits of this method for diagnosis.

Methods: The group consisted of 16 patients (32 eyes) with PCD. All patients were examined for visual acuity, colour sense and visual field.