Publications by authors named "I K"
Article Synopsis
- This study is the first to report on caprine forestomach native collagen (CFNC) modified with silver nanowires (AgNWs) to create scaffolds intended for wound healing dressings.
- The CFNC/AgNWs scaffolds demonstrated a porous 3D structure with favorable physical and chemical properties, showing antibacterial effects and mechanical properties that varied based on AgNW concentration.
- However, higher concentrations of Ag ions were found to cause cytotoxicity in L929 fibroblast cells, indicating the need to balance antibacterial efficacy with biocompatibility when selecting AgNW dosages for optimal wound dressing performance.
Exploring chitosan nanoparticles for enhanced therapy in neurological disorders: a comprehensive review.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Article Synopsis
- Chitosan nanoparticles are gaining attention as a therapeutic option for neurological disorders due to their biocompatibility, biodegradability, and ability to be easily modified for targeted drug delivery.
- These nanoparticles help overcome the blood-brain barrier, crucial for treating conditions like Alzheimer’s, Parkinson’s, and brain tumors, by enhancing drug absorption and protecting therapies from degradation.
- While promising results have been observed in animal studies, challenges such as large-scale production, regulatory issues, and the need for safety research still exist for their clinical use.
Distinct molecular features of FLNC mutations, associated with different clinical phenotypes.
Cytoskeleton (Hoboken)
September 2024
Filamin С is a key an actin-binding protein of muscle cells playing a critical role in maintaining structural integrity and sarcomere organization. FLNC mutations contribute to various types of cardiomyopathies and myopathies through potentially different molecular mechanisms. Here, we described the impact of two clinically distinct FLNC variants (R1267Q associated with arrhythmogenic cardiomyopathy and V2264M associated with restrictive cardiomyopathy) on calcium homeostasis, electrophysiology, and gene expression profile of iPSC-derived patient-specific cardiomyocytes.
View Article and Find Full Text PDFCrohn's disease (CD) is a chronic inflammatory bowel disease associated with psychological distress and intestinal microbial changes. Here, we examined whether a 3-month period of Cognitive Behavioral and Mindfulness with Daily Exercise (COBMINDEX) intervention, which improves the wellbeing and inflammatory state of CD patients, may also affect their gut microbiome. Gut microbiota, circulating inflammatory markers and hormones were analyzed in 24 CD patients before (T1) and after 3 months of COBMINDEX (T2), and in 25 age- and sex-matched wait-list control patients at the corresponding time-points.
View Article and Find Full Text PDFArticle Synopsis
- Monoallelic HMBS variants cause acute intermittent porphyria (AIP), while biallelic variants may lead to a less understood condition called HMBS-related leukoencephalopathy.
- An 8-year-old girl exhibited symptoms such as hypotonia, vision issues, and abnormal brain activity, prompting genetic testing that initially pointed to a different variant before identifying a homozygous HMBS variant.
- This case highlights that HMBS-related leukoencephalopathy can occur without classic porphyria symptoms, expanding the understanding of this genetic disease's presentation.