Publications by authors named "I K Karunaratne"

Purpose: To evaluate the efficacy of a novel contact lens sensor system (CLS) in detecting continuous intraocular pressure (IOP) variations following positional transitions, and to explore these IOP variation patterns among normal subjects, untreated glaucoma patients, and untreated ocular hypertension (OHT) subjects.

Methods: This prospective comparative study included 20 normal subjects, 14 high tension glaucoma (HTG) patients, 16 normal tension glaucoma (NTG) patients, and 14 OHT subjects. Participants wore the CLS for continuous IOP monitoring while undergoing sequential body position changes: from sitting to supine to a 10° head-down tilt (HDT), with each position maintained for ten minutes.

View Article and Find Full Text PDF

Aims: To investigate the physiological nyctohemeral intraocular pressure (IOP) rhythms of normal Chinese adults using a novel contact lens sensor system (CLS) that can output IOP in millimetres of mercury (mm Hg) continuously.

Methods: Fifty-nine eyes of 59 normal Chinese adults completed 24-hour IOP monitoring using the novel CLS. A descriptive analysis was conducted on the 24-hour IOP mean, peak and acrophase, trough and bathyphase, fluctuation, and mean amplitude of intraocular pressure excursion (MAPE).

View Article and Find Full Text PDF
Article Synopsis
  • The study evaluated the safety and tolerability of a new contact lens sensor (CLS) designed for continuous monitoring of intraocular pressure (IOP) in human eyes over 3 and 24 hours.
  • Results indicated increases in corneal fluorescein staining and discomfort after IOP monitoring, but most measures, including best-corrected visual acuity and tear break-up time, returned to baseline after one day.
  • Overall, the CLS demonstrated promising safety and tolerability for 24-hour IOP monitoring without significant differences between normal subjects and glaucoma patients.
View Article and Find Full Text PDF

Giant Asian honey bee sting envenoming is a recognized cause of morbidity and mortality in rural Sri Lanka. Mass envenoming causes clinical effects, either as allergic and anaphylactic reactions or bee sting toxin-induced multiorgan damage. We report a patient who had mass envenoming from more than 1000 stingers who subsequently developed hematologic features suggestive of thrombotic microangiopathy-related hemolytic anemia.

View Article and Find Full Text PDF