Inhibition of BK channels protects neonatal hearts against myocardial ischemia and reperfusion injury.

BK channels are large-conductance calcium and voltage-activated potassium channels that are heterogeneously expressed in a wide array of cells. Activation of BK channels present in mitochondria of adult ventricular cardiomyocytes is implicated in cardioprotection against ischemia-reperfusion (IR) injury. However, the BK channel's activity has never been detected in the plasma membrane of adult ventricular cardiomyocytes.

Bronchoscopic-directed diagnosis of peripheral lung lesions suspicious for cancer.

Bronchoscopic techniques have come a long way in diagnosing peripheral lung lesions suspicious for cancer. Following in the footsteps of gastrointestinal endoscopy. bronchoscopy has become more useful in diagnosing lesions previously thought to be unreachable.

Aminothiols protect endothelial cell proliferation against inhibition by lipopolysaccharide.

Lipopolysaccharide (LPS) is a primary agent of sepsis that damages the vascular endothelium. Endothelial cell proliferation is key to the repair of damaged endothelium, and drugs that counteract the antiproliferative impact of LPS on endothelial cells should be beneficial. Because LPS exerts much of its cytotoxicity by generating reactive oxygen and nitrogen intermediates, it would be helpful to know whether therapeutic antioxidant thiols maintain cell proliferation in injured endothelium.