[Short-term efficacy and safety of Brolucizumab for neovascular age-related macular degeneration in the Russian Federation].

Purpose: To analyze the short-term efficacy and safety of Brolucizumab in the treatment of patients with neovascular age-related macular degeneration (nAMD).

Material And Methods: This retrospective pilot study included 154 patients (51 males and 103 females, mean age 73.9±8.

Resistance to HO-induced oxidative stress in human cells of different phenotypes.

Application of genetically encoded biosensors of redox-active compounds promotes the elaboration of new methods for investigation of intracellular redox activities. Previously, we have developed a method to measure quantitatively the intracellular concentration of hydrogen peroxide (HO) in living cells using genetically encoded biosensor HyPer. In the present study, we refined the method and applied it for comparing the antioxidant system potency in human cells of different phenotypes by measuring the gradient between the extracellular and cytoplasmic HO concentrations under conditions of HO-induced external oxidative stress.

[A model of primary open-angle glaucoma: manifestations and outcomes].

Objective: To determine the expected duration of the disease and the age of the patients with different stages ofprimary open-angle glaucoma complicated by pseudoexfoliation syndrome (PES) and/or patients with pseudoexfoliation glaucoma (PEG).

Methods: The study protocol included data from 120 patients (50 males (41.7%), 70 females (58.

[Disorders of cerebral hemodynamics in workers of ore mining and processing enterprise].

Using Doppler technologies, the authors studied blood flow in carotid and vertebral basillary systems of brain circulation, in orbital and central retinal arteries among workers of major occupations in ore mining and processing enterprise, who are subjected to occupational hazards complex. Workers with length of service over 20 years appeared to have stenosis and occlusion of medial cerebral artery and basillary artery.

[Evaluating microcirculation state in eye conjunctiva of machinery construction industry workers].

Studies of microcirculation vessels disorders in workers exposed to occupational physical hazards remain topical problem. The authors studied changes in microcirculatory vessels of conjunctiva, through biomicroscopy and calibrometric angiographic parameters in the examinees, and determined significant changes - narrowed arterioles, RBC aggreggation sites - in the workers with long length of service.