Efficacy and Safety of High PEEP NIV in COVID-19 Patients.

Objective: To investigate the efficacy and safety of non-invasive ventilation (NIV) with high PEEP levels application in patients with COVID-19-related acute respiratory distress syndrome (ARDS).

Methods: This is a retrospective cohort study with data collected from 95 patients who were administered NIV as part of their treatment in the COVID-19 intensive care unit (ICU) at University Hospital Centre Zagreb between October 2021 and February 2022. The definite outcome was NIV failure.

Primary undifferentiated carcinoma of rete testis with extensive peritoneal carcinomatosis and fatal outcome: Case report.

Carcinoma of rete testis is an extremely rare malignant tumor arising from its epithelium. Prognosis is poor with mean survival of 8 months. Lymph node metastases and the size of the tumor larger than 5 cm are poor prognostic factors.

Safety and efficacy of fluvoxamine in COVID-19 ICU patients: An open label, prospective cohort trial with matched controls.

Aims: Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) and sigma-1 receptor agonist, has so far shown promise in the prevention of COVID-19 progression as an early treatment option in three trials. The aim of this study was to evaluate the safety and efficacy of fluvoxamine in COVID-19 patients if administered later in the course of the disease.

Methods: The study was designed as an open-label, prospective cohort trial with matched controls.

Objective Assessment of the Quality and Accuracy of Deformable Image Registration.

Background: The increased use of deformable registration algorithms in clinical practice has also increased the need for their validation.

Aims And Objectives: The purpose of the study was to investigate the quality, accuracy, and plausibility of three commercial image registration algorithms for 4-dimensional computed tomography (4DCT) datasets using various similarity measures.

Materials And Methods: 4DCT datasets were acquired for 10 lung cancer patients.

Clinical Evaluation of a Two-dimensional Liquid-Filled Ion chamber Detector Array for Verification of High Modulation Small Fields in Radiotherapy.

Introduction: Clinical evaluation of a two-dimensional (2D) liquid-filled ion chamber detector array used in the verification of highly modulated small beams of stereotactic body radiation therapy (SBRT) has been conducted.

Materials And Methods: Measurements with the Octavius 1000 SRS (PTW, Freiburg, Germany) detector with 977 liquid-filled ion chambers were compared against EDR2 film and PTW Octavius Seven29. The performance of detector array has been evaluated on ten SBRT patient plans.