Publications by authors named "I Juric"
Integrative analysis of the 3D genome and epigenome in mouse embryonic tissues.
Nat Struct Mol Biol
December 2024
While a rich set of putative cis-regulatory sequences involved in mouse fetal development have been annotated recently on the basis of chromatin accessibility and histone modification patterns, delineating their role in developmentally regulated gene expression continues to be challenging. To fill this gap, here we mapped chromatin contacts between gene promoters and distal sequences across the genome in seven mouse fetal tissues and across six developmental stages of the forebrain. We identified 248,620 long-range chromatin interactions centered at 14,138 protein-coding genes and characterized their tissue-to-tissue variations and developmental dynamics.
View Article and Find Full Text PDFTranscription factors (TFs) bind combinatorially to cis-regulatory elements, orchestrating transcriptional programs. Although studies of chromatin state and chromosomal interactions have demonstrated dynamic neurodevelopmental cis-regulatory landscapes, parallel understanding of TF interactions lags. To elucidate combinatorial TF binding driving mouse basal ganglia development, we integrated chromatin immunoprecipitation sequencing (ChIP-seq) for twelve TFs, H3K4me3-associated enhancer-promoter interactions, chromatin and gene expression data, and functional enhancer assays.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how competing risks, like allograft failure and death with a functioning graft, affect the performance of prognostic models used for kidney transplant recipients.
- The research involves 11,046 kidney transplant recipients across 10 countries, developing models using various regression techniques to predict long-term graft failure while carefully evaluating their accuracy and reliability.
- Results indicate that both standard Cox models and competing risk models provide similar predictions for graft failure, with high concordance indices, confirming their usefulness in clinical settings.
Cardiovascular diseases, including sudden cardiac death (SCD), are the leading cause of mortality among kidney transplant recipients (KTRs). While implantable cardioverter defibrillators (ICDs) are established for SCD prevention in the general population, data on the benefits in patients with CKD is scarce and controversial, and there is no established general consensus on their use in this group of patients. Furthermore, data for KTRs are lacking.
View Article and Find Full Text PDFArticle Synopsis
- Protein-energy wasting (PEW) and sarcopenia are prevalent in chronic hemodialysis patients, leading to severe health issues and higher mortality rates.
- This study compared the effectiveness of the SARC-F test and the Malnutrition-Inflammation Score (MIS) in identifying sarcopenia and predicting negative health outcomes in hemodialysis patients.
- Results showed that while many patients scored low on SARC-F, they still had some form of PEW; however, only the MIS was consistently linked to poor nutritional status and higher risk for negative outcomes, indicating that detailed assessment tools like MIS are crucial for identifying at-risk patients.