Augmented Intelligence and Dermatology - Part II: Bias, Benchmarks, Guidelines, Ethics, Regulation, and Future Directions.

Despite the proliferation of artificial intelligence (AI) tools, numerous challenges remain in the development and evaluation of AI related technologies. Furthermore, a practice gap exists in how to responsibly implement AI effectively, ethically, and legally in dermatology. Part 2 of this continuing medical education review series will explain the key technical challenges and principles of trustworthy and responsible AI as well as describe the ethical challenges and review resources to help guide safe, effective, and ethical AI in dermatology.

KB-0118, A novel BET bromodomain inhibitor, suppresses Th17-mediated inflammation in inflammatory bowel disease.

Inflammatory bowel disease (IBD) presents complex pathologies and remains challenging to treat, highlighting the urgent need for innovative therapeutics. This study evaluates KB-0118, a novel BET bromodomain inhibitor targeting BRD4, for its immunomodulatory effects in IBD. KB-0118 effectively inhibited pro-inflammatory cytokines, including TNF, IL-1β, and IL-23a, and selectively suppressed Th17 cell differentiation, a critical driver of IBD pathology.

β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor.

Background: Olfactory receptors (ORs) are present in non-olfactory tissues and contribute to diverse biological roles beyond smell perception. Among them, OR51E2 has been associated with cancer biology, and its activator, β-ionone, a natural terpenoid, is known to have anticancer effects.

Purpose: This study aimed to clarify the tumor-suppressive role of OR51E2 in colorectal cancer (CRC), unravel the regulatory mechanism underlying its downregulation, and evaluate the therapeutic potential of β-ionone, an OR51E2 ligand, in CRC progression.

Antioxidant Supplementation for Management of Gestational Diabetes Mellitus in Pregnancy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Purpose Of Review: Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy globally. Hyperglycaemia and associated production of reactive oxygen species can lead to oxidative stress in pregnancy. However, the potential effectiveness of increased antioxidant intake in the management of GDM has not been widely examined.