Publications by authors named "I Jayakumar"
Background: Peri-transplant is a critical period which is associated with a myriad of complications that require pediatric intensive care unit (PICU) referral. PICU outcomes have been historically poor post-hematopoietic stem cell transplantation (HSCT), especially when associated with inotrope support, invasive ventilation, and renal replacement therapy. The study aimed to assess the outcomes of PICU referral in children undergoing HSCT.
View Article and Find Full Text PDFCytomegalovirus Reactivation as a Risk Factor for All-Cause Mortality in Children Undergoing Hematopoietic Stem Cell Transplantation: Experience Over Two Decades from a Tertiary Referral Center in India.
Indian J Hematol Blood Transfus
January 2024
The aim of the study was to analyse the burden of cytomegalovirus (CMV) disease in children undergoing hematopoietic stem cell transplantation (HSCT) and its correlation with all-cause mortality. We performed a retrospective study in children up to 18 years of age who underwent allogeneic HSCT between February 2002 to December 2021 in the pediatric blood and marrow transplantation unit. A total of 1035 patients were included where five hundred forty-three (52.
View Article and Find Full Text PDFHematopoietic stem cell Transplantation in Children with very Early Onset Inflammatory Bowel Disease Secondary to Monogenic Disorders of immune-dysregulation.
Indian J Hematol Blood Transfus
April 2023
Article Synopsis
- Very early-onset inflammatory bowel disease (VEOIBD) occurs in children under six and can be treated with hematopoietic stem cell transplantation (HSCT).
- A study between December 2012 and December 2020 included 25 children with various monogenic disorders who underwent HSCT, revealing an overall survival rate of 64% and highlighting the vital role of complete chimerism in preventing disease recurrence.
- Findings showed that mixed chimerism led to a significantly higher mortality risk, emphasizing the importance of early diagnosis and comprehensive care for better outcomes in VEOIBD.
We aimed to analyze infections in children undergoing hematopoietic stem cell transplantation (HSCT) until engraftment. The spectrum and risk factors associated will help plan interventions to reduce mortality. We performed a retrospective analysis on the infections, associated risk factors, and mortality until engraftment in children up to 18 years of age undergoing HSCT from January 2017 to August 2020.
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