Publications by authors named "I Jaussent"
Article Synopsis
- Cardiovascular diseases are the leading cause of illness and death in chronic kidney disease patients, with a study analyzing the impact of coronary artery calcifications (CAC) and cardiovascular biomarkers on major adverse cardiovascular events and deaths.
- The study involved 425 non-dialysis CKD patients who underwent scans for CAC scoring and measurement of various cardiovascular risk biomarkers, with follow-up lasting an average of about 3.6 years.
- Findings indicate that high CAC levels significantly increase the risk of major adverse cardiovascular events, especially when combined with certain inflammatory and metabolic conditions, suggesting that managing inflammation and improving mineral metabolism could be key strategies for reducing cardiovascular risk in these patients.
Objective/background: Kleine-Levin syndrome (KLS) is a rare sleep disorder characterized by recurrent episodes of severe hypersomnolence in association with various degrees of cognitive impairment, perceptive abnormalities, apathy, behavioral disturbances. Some of these symptoms, hypersomnolence, compulsive eating and increased sexual drive may be replaced by their opposites or alternate with them. Remarkably enough, these « atypical symptoms » have never been enlighted nor compared in frequency with corresponding typical symptoms.
View Article and Find Full Text PDFPET Study of Microglial Activation in Kleine-Levin Syndrome.
Neurol Neuroimmunol Neuroinflamm
July 2024
Article Synopsis
- Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurring episodes of excessive sleepiness and cognitive/behavioral issues, potentially linked to inflammation, prompting a study on microglia activation using PET imaging.
- Researchers conducted PET scans on KLS patients and controls, focusing on specific brain regions to measure microglial activation and compare conditions during symptomatic and asymptomatic phases.
- The study found no significant differences in microglial activation between KLS patients and controls or between symptomatic and asymptomatic periods, suggesting a lack of neuroinflammation in KLS and indicating the need for further research on potential biomarkers.
Article Synopsis
- Narcolepsy type 1 (NT1) is linked to the loss of orexin-producing neurons in the hypothalamus, potentially due to an immune response, but past studies showed no inflammation during later stages of the disease.
- This research investigated microglia density in the hypothalamus and thalamus of NT1 patients using PET imaging, compared to control subjects, while also exploring relationships between microglial activity and disease factors like duration and severity.
- Results indicated no significant differences in microglial density between NT1 patients and controls in the hypothalamus and thalamus, but lower overall brain microglial activity was observed in NT1 patients, raising questions about the disease's immune mechanisms and its onset