Stereoselective and endothelium-independent action of nicardipine on the isolated porcine coronary artery.

The qualitative and quantitative effects of the (+)-S and (-)-R enantiomers and of the racemic mixture of the Ca2+ channel antagonist, nicardipine, were compared on the isolated porcine coronary artery with intact and removed endothelium. All three forms of nicardipine inhibited the contractions induced by KCl (5-90 mM) in both vessel preparations. The potency (IC50) of the (+)-S and (-)-R enantiomers and of the racemic mixture was 6.

[Evaluation of the value of ultrasound in the diagnosis of gynecologic tumors].

The value of ultrasound (US) is analysed by means of ROC-curves (receiver operating curves) taking into consideration both the sensitivity and specificity of the method, as well as the prevalence of particular tumours in the examined group. US diagnosis is compared with clinical and surgical findings. The authors have found that the degree of reliability achieved by either the clinical or the US method of diagnosing myomas is almost the same.

[Tocolysis in pregnancy and labor].

For tocolysis in pregnancy and labour the authors have used Dilatol (Bufenin) since 1970 and Partusisten since 1976. In 1977 tocolysis was applied in 354 pregnant women (10.6%) : 63 (17.