Components of the Endosome-Lysosome Vesicular Machinery as Drivers of the Metastatic Cascade in Prostate Cancer.

Prostate cancer remains a significant global health concern, with over 1.4 million new cases diagnosed and more than 330,000 deaths each year. The primary clinical challenge that contributes to poor patient outcomes involves the failure to accurately predict and treat at the onset of metastasis, which remains an incurable stage of the disease.

Becoming Housed During Palliative Care Enrollment: Identifying Drivers, Deterrents, and Directions for Future Care.

Homelessness is associated with accelerated disease progression, and housing placements are less likely when experiencing serious illness. Little research to date has focused on how to successfully secure housing placement during serious illness and end of life. This study aimed to address this gap by examining factors influencing housing placement among seriously ill palliative care patients experiencing homelessness.

Identification, characterization and pathogenicity of Fusarium species associated with sheath and stem blight - A new record on pearl millet (Pennisetum glaucum R. Br.).

Pearl millet (Pennisetum glaucum R. Br.) is a vital crop, especially in arid and semi-arid regions, where it serves as a staple food for millions.

Mayo Genetic Risk Models for Newly Diagnosed Acute Myeloid Leukemia Treated With Venetoclax + Hypomethylating Agent.

Patients with newly diagnosed acute myeloid leukemia (ND-AML) derive variable survival benefit from venetoclax + hypomethylating agent (Ven-HMA) therapy. The primary objective in the current study was to develop genetic risk models that are predictive of survival and are applicable at the time of diagnosis and after establishing treatment response. Among 400 ND-AML patients treated with Ven-HMA at the Mayo Clinic, 247 (62%) achieved complete remission with (CR) or without (CRi) count recovery.

How Should We Respond to Spatial Injustice in Health Care Organizations?

Hostile design is a built environment strategy to discourage unwanted behaviors or limit use by unwanted users in a space. This commentary on a case identifies how hostile design choices perpetuate spatial injustice in both health care settings and the surrounding community and argues that health care organizations have duties to mitigate adverse health consequences of such spatial injustices. This commentary then describes strategies for identifying overt and covert hostile design of health care spaces and proposes future practices and translational research to make health care environments' designs accessible, approachable, and more just.