Publications by authors named "I J WOLMAN"
Article Synopsis
- The study examined the occurrence and characteristics of callosal injury in fetuses affected by cytomegalovirus (CMV) fetopathy using a retrospective analysis of patients with confirmed CMV-PCR.
- Among 72 patients, 34.7% showed callosal abnormalities, primarily associated with other central nervous system issues like periventricular hyperechogenicity and calcifications.
- The findings suggest that callosal injury is a common consequence of CMV infection, indicating a worse prognosis and increased risk of neurodevelopmental impairment, with distinct prenatal patterns of injury compared to what is seen postnatally.
Objective: To study the early second trimester development of brain hemispheres, lateral ventricles, choroid plexus, and ganglionic eminence/basal ganglia complex (GEBG).
Methods: A retrospective analysis of TVUS 3D volumes of 14-18 gestational weeks (GW) fetuses. Hemispheres were analyzed for wall thickness, choroid plexus extension, GEBG height and length, lamination pattern (intermediate zone and the subplate border, IZ-SP), ventricle height, width, and angle.
Background: deletion/intragenic mutations are the most commonly identified genetic cause of congenital anomalies of the kidney and urinary tract (CAKUT) suggested by fetal ultrasound findings such as: parenchymal hyperechogenicity, overt cystic changes or gross morphological urinary system (UT) abnormalities. The postnatal evolution of these 17q12 deletions encompassing the gene-associated findings has not been assessed in depth.
Methods: In this observational study, we present postnatal follow-up findings in 5 of 6 cases (one pregnancy was terminated on parental request) of fetal-onset cystic/hyperechogenic kidneys eventually diagnosed with 17q12 microdeletion encompassing the gene between 2009 and 2017.
Objective: To study the clinical significance of brain germinal matrix (GM) changes in cytomegalovirus (CMV) infected fetuses.
Method: This is a retrospective analysis. Group A; isolated GM finding, with or without lenticulostriatal vasculopathy (LSV).