Publications by authors named "I J Rosenstein"
Article Synopsis
- The study explores the Gas6/TAM receptor system's impact on neurodegeneration in multiple sclerosis (MS), focusing on how it relates to demyelination and remyelination processes.
- Researchers analyzed cerebrospinal fluid (CSF) samples from various MS patients and healthy controls to measure soluble Gas6/TAM biomarkers and assess brain volume changes over time.
- Findings suggest that elevated levels of Gas6 and its receptors correlate with greater white matter damage and that lower levels of these markers may indicate better remyelination, highlighting their potential role in MS progression.
Background And Objectives: The impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).
Methods: Antibody responses to Epstein-Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared with 66 healthy controls matched for sex and age.
Background: Elevated neurofilament light chain (NfL) levels are associated with worse prognosis in Guillain-Barré syndrome (GBS). Our objectives were to determine the utility of serum NfL (sNfL), cerebrospinal fluid (CSF)/serum NfL ratio and NfL index as prognostic and diagnostic biomarkers for GBS.
Methods: We measured NfL in serum and/or CSF obtained from 96 GBS patients between 1989 and 2014 in western Sweden.
Background And Objectives: The complement system is known to play a role in multiple sclerosis (MS) pathogenesis. However, its contribution to disease progression remains elusive. The study investigated the role of the complement system in disability progression of patients with primary progressive MS (PPMS).
View Article and Find Full Text PDFObjective: Insidious disability worsening is a common feature in relapsing-remitting multiple sclerosis (RRMS). Many patients experience progression independent of relapse activity (PIRA) despite being treated with high efficacy disease-modifying therapies. We prospectively investigated associations of body-fluid and imaging biomarkers with PIRA.
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