Dark soliton detection using persistent homology.

Classifying images often requires manual identification of qualitative features. Machine learning approaches including convolutional neural networks can achieve accuracy comparable to human classifiers but require extensive data and computational resources to train. We show how a topological data analysis technique, persistent homology, can be used to rapidly and reliably identify qualitative features in experimental image data.

Ivermectin as a SARS-CoV-2 Pre-Exposure Prophylaxis Method in Healthcare Workers: A Propensity Score-Matched Retrospective Cohort Study.

Background: Ivermectin is a drug that has been shown to be active against coronavirus disease 19 (COVID-19) in previous studies. Healthcare personnel are highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Therefore, we decided to offer them ivermectin as a pre-exposure prophylaxis (PrEP) method.

Combination anti-coronavirus therapies based on nonlinear mathematical models.

Using nonlinear mathematical models and experimental data from laboratory and clinical studies, we have designed new combination therapies against COVID-19.

Acoustic vortex beams in synthetic magnetic fields.

We analyze the propagation of acoustic vortex beams in longitudinal synthetic magnetic fields. We show how to generate two field configurations using a fluid contained in circulating cylinders: a uniform synthetic magnetic field hosting Laguerre-Gauss modes, and an Aharonov-Bohm flux tube hosting Bessel beams. For non-paraxial beams we find qualitative differences from the well-studied case of electron vortex beams in magnetic fields, arising due to the vectorial nature of the acoustic wave's velocity field.

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.

Interleukin-2 (IL-2) has been shown to suppress immune pathologies by preferentially expanding regulatory T cells (T). However, this therapy has been limited by off-target complications due to pathogenic cell expansion. Recent efforts have been focused on developing a more selective IL-2.