[Evaluation of selected parameters of lymphocyte activity in umbilical blood. II. Release of angiogenic cytokines].

Angiogenic abilities of mononuclear cells in the umbilical blood was estimated in 31 healthy newborns. LIA test was performed on 6-8 weeks old mice, which underwent immunosuppression before intracutaneous injection of leucocytes and were narcotized after 72 hours. The mean number of newly formed vessels was 12.

A ribonuclease inhibitor expresses anti-angiogenic properties and leads to reduced tumor growth in mice.

Our experiments were designed to determine whether recombinant ribonuclease inhibitor (RNasin) could inhibit angiogenesis and reduce tumor growth in adult mice. We used the Fajardo disc angiogenesis assay as the primary means of measuring new blood vessel growth. This assay measures the penetration of cells into a polyvinyl alcohol sponge with a central core of ELVAX-coated sponge containing test substances.

Assays for angiogenesis: a review.

Accurate, reliable quantitation of the neovascular (angiogenic) response, both in vitro and in vivo, is an essential requirement for the study of new blood vessel growth. Over many years, ingenious ways have been developed for measuring this process, and they have contributed much to our present understanding of the vasculogenesis and angiogenesis that accompany normal embryonic development, lactation and wound healing, as well as tumor growth and a variety of other disease states ranging from diabetic retinopathy to autoimmune vasculitis. In this review we describe and evaluate the methodology and specific features of some of the most frequently used of these assays.

[Studies on impaired angiogenesis activity of the leucocytes in patients with oral candidiasis].

The preliminary characteristics is reported of the cells causing active suppression leading to a decrease of the angiogenesis activity of leucocytes isolated from patients with oral candidiasis. The effect of three immunomodulators on this suppression was studied.