A case of developmental topographical disorientation: impact on diagnostic trajectory and everyday life.

Developmental Topographical Disorientation (DTD) refers to impaired ability to create and consult mental maps in the absence of neurological abnormalities. We present the case study of I.S.

Time-Series Representation Feature Refinement with a Learnable Masking Augmentation Framework in Contrastive Learning.

In this study, we propose a novel framework for time-series representation learning that integrates a learnable masking-augmentation strategy into a contrastive learning framework. Time-series data pose challenges due to their temporal dependencies and feature-extraction complexities. To address these challenges, we introduce a masking-based reconstruction approach within a contrastive learning context, aiming to enhance the model's ability to learn discriminative temporal features.

Spatial dissection of tumour microenvironments in gastric cancers reveals the immunosuppressive crosstalk between fibroblasts and -activated macrophages.

Background: A spatially resolved, niche-level analysis of tumour microenvironments (TME) can provide insights into cellular interactions and their functional impacts in gastric cancers (GC).

Objective: Our goal was to translate the spatial organisation of GC ecosystems into a functional landscape of cellular interactions involving malignant, stromal and immune cells.

Design: We performed spatial transcriptomics on nine primary GC samples using the Visium platform to delineate the transcriptional landscape and dynamics of malignant, stromal and immune cells within the GC tissue architecture, highlighting cellular crosstalks and their functional consequences in the TME.

Baculovirus entry into the central nervous system of caterpillars is independent of the viral protein tyrosine phosphatase.

Neuroparasitism concerns the hostile take-over of a host's nervous system by a foreign invader, in order to alter the behaviour of the host in favour of the parasite. One of the most remarkable cases of parasite-induced host behavioural manipulation comprises the changes baculoviruses induce in their caterpillar hosts. Baculoviruses may manipulate caterpillar behaviour in two ways: hyperactivity (increased movement in the horizontal plane) and/or tree-top disease (movement to elevated levels in the vertical plane).

Tubulointerstitial nephritis antigen-like 1 from cancer-associated fibroblasts contribute to the progression of diffuse-type gastric cancers through the interaction with integrin β1.

Background: Tumor cells of diffuse-type gastric cancer (DGC) are discohesive and infiltrate into the stroma as single cells or small subgroups, so the stroma significantly impacts DGC progression. Cancer-associated fibroblasts (CAFs) are major components of the tumor stroma. Here, we identified CAF-specific secreted molecules and investigated the mechanism underlying CAF-induced DGC progression.