A theory of eu-estrogenemia: a unifying concept.

Objective: The aim of the study was to propose a unifying theory for the role of estrogen in postmenopausal women through examples in basic science, randomized controlled trials, observational studies, and clinical practice.

Methods: Review and evaluation of the literature relating to estrogen.

Discussion: The role of hormone therapy and ubiquitous estrogen receptors after reproductive senescence gains insight from basic science models.