Publications by authors named "I J Constable"
Article Synopsis
- This study investigates biomarkers that could predict visual acuity improvement and central retinal thickness changes in patients with diabetic macular edema treated with aflibercept.
- Key findings indicate that higher macular vessel density and elevated LDL levels are associated with better visual acuity outcomes, while certain imaging biomarkers can predict reductions in retinal thickness.
- The results aim to refine patient selection for aflibercept treatment by identifying those likely to benefit the most based on imaging and health indicators.
Purpose: To establish disease progression rates in total lesion size (TLS), decreased autofluorescence (DAF) area, total macular volume (TMV), and mean macular sensitivity (MMS) in PRPH2-associated retinal dystrophy.
Design: Single-center, retrospective chart review.
Participants: Patients with heterozygous pathogenic or likely pathogenic PRPH2 variants.
Purpose: To investigate concordance in symptom onset, area of dark autofluorescence (DAF), and growth rate (GR) between Stargardt disease siblings at an age-matched time point.
Methods: In this retrospective longitudinal study of sibling pairs with identical biallelic ABCA4 variants, age at symptom onset, best-corrected visual acuity, atrophy area, and effective radius of DAF on ultra-widefield fundus autofluorescence were recorded. Absolute intersibling differences for both eyes were compared with absolute interocular differences using the Mann-Whitney test.
Reported growth rates (GR) of atrophic lesions in Stargardt disease (STGD1) vary widely. In the present study, we report the longitudinal natural history of patients with confirmed biallelic mutations from five genotype groups: c.6079C>T, c.
View Article and Find Full Text PDFPurpose: To establish a mutation-specific age-dependent ultra-widefield fundus autofluorescence (UWF-FAF) trajectory in a large Stargardt disease (STGD1) cohort using total lesion size (TLS) and to develop a clinical method for variant classification.
Methods: A retrospective study of patients with biallelic ABCA4 mutations that were evaluated with UWF-FAF. Boundaries of TLS, defined by stippled hyper/hypoautofluorescence, were outlined manually.