Publications by authors named "I J Colquhoun"
Article Synopsis
- Coronaviruses can originate from animals and cause serious illnesses in both humans and animals, with a key protein called Mac1 playing a role in viral replication and interferon inhibition.
- Researchers discovered a compound, MCD-628, that inhibits Mac1 but found its effectiveness was limited due to poor permeability.
- By creating more hydrophobic derivatives, they identified four compounds that successfully inhibited Mac1 and reduced replication of coronaviruses, confirming their specificity through drug-resistance mutations, but this resistance came at a cost to the virus's overall fitness.
Factors influencing terrestriality in primates of the Americas and Madagascar.
Proc Natl Acad Sci U S A
October 2022
Among mammals, the order Primates is exceptional in having a high taxonomic richness in which the taxa are arboreal, semiterrestrial, or terrestrial. Although habitual terrestriality is pervasive among the apes and African and Asian monkeys (catarrhines), it is largely absent among monkeys of the Americas (platyrrhines), as well as galagos, lemurs, and lorises (strepsirrhines), which are mostly arboreal. Numerous ecological drivers and species-specific factors are suggested to set the conditions for an evolutionary shift from arboreality to terrestriality, and current environmental conditions may provide analogous scenarios to those transitional periods.
View Article and Find Full Text PDFTeaching and learning anatomy by using human cadaveric specimens has been a foundation of medical and biomedical teaching for hundreds of years. Therefore, the majority of institutions that teach topographical anatomy rely on body donation programmes to provide specimens for both undergraduate and postgraduate teaching of gross anatomy. The COVID-19 pandemic has posed an unprecedented challenge to anatomy teaching because of the suspension of donor acceptance at most institutions.
View Article and Find Full Text PDFis an indigenous porridge processed from millet in Ghana. The process involves fermentation stages, giving the characteristic organoleptic properties of the product that is produced largely at a small-scale household level and sold as a street food. Like many other indigenous foods, quality control is problematic and depends on the skills of the processor.
View Article and Find Full Text PDFBackground: The COVID-19 pandemic lockdown precluded face-to-face final Objective Structured Clinical Examinations (OSCE) in the UK.
Results: In response, we rapidly developed and then successfully implemented a novel Virtual Objective Structured Clinical Examination (VOSCE).
Conclusions: In this article we both describe and reflect on our experience as well as discuss the implications for future undergraduate assessment as the situation evolves.