Artificial intelligence model substantially improves stratum corneum moisture content prediction from visible-light skin images and skin feature factors.

Background: Appropriate skin treatment and care warrants an accurate prediction of skin moisture. However, current diagnostic tools are costly and time-consuming. Stratum corneum moisture content has been measured with moisture content meters or from a near-infrared image.

Molecular Reorganization during the Formation of the Human Skin Barrier Studied In Situ.

In vertebrates, skin upholds homeostasis by preventing body water loss. The skin's permeability barrier is located intercellularly in the stratum corneum and consists of stacked lipid lamellae composed of ceramides, cholesterol, and free fatty acids. We have combined cryo-electron microscopy with molecular dynamics modeling and electron microscopy simulation in our analysis of the lamellae's formation, a maturation process beginning in stratum granulosum and ending in stratum corneum.

Human skin barrier formation takes place via a cubic to lamellar lipid phase transition as analyzed by cryo-electron microscopy and EM-simulation.

The skin's permeability barrier consists of stacked lipid sheets of splayed ceramides, cholesterol and free fatty acids, positioned intercellularly in the stratum corneum. We report here on the early stage of skin barrier formation taking place inside the tubuloreticular system in the secretory cells of the topmost viable epidermis and in the intercellular space between viable epidermis and stratum corneum. The barrier formation process was analysed in situ in its near-native state, using cryo-EM combined with molecular dynamics modeling and EM simulation.

Facial expression under stiff stratum corneum leads to strain concentrations, followed by residual wrinkle formation.

Objective: Computer simulation studies of skin models, which indicate skin compression in the same manner as facial expressions, have suggested that stratum corneum could control skin-folding patterns, which may play an essential role in wrinkle formation. However, it is not clear to what extent the mechanics of stratum corneum influence wrinkle formation in vivo. The aim of this study was to verify that stratum corneum could control strain distribution during facial expressions, which in turn leads to wrinkle formation.

Microrelief suppresses large wrinkling appearance: an in silico study.

Background And Purpose: Extensive skin wrinkling during facial expressions is one of the considerable problems in aesthetic dermatology. Although a few in silico studies have been performed with the aim of revealing the mechanism of a wrinkled appearance, there have been few studies that take into account the influence of skin roughness (i.e.