[A case report of Peutz-Jeghers syndrome in childhood].

The clinical course, diagnosis and treatment of Peutz--Jeghers's syndrome in childhood are discussed and a case reported in a eight-year-old girl. The disease presented with skin and mucosal melanin pigmentation in the mouth, frequent colic-like abdominal pain, due to chronic recurrent invaginations. On operation, the cause of the invaginations appeared to be 11 polypous formations in small intestines (8) and in the large intestines (3), which were subjected to radical operative removal.

Changes in the responsiveness of the colonic smooth muscle to carbachol in Hirschsprung's disease.

In vitro experiments were performed on smooth-muscle strips cut out in longitudinal and circular direction from the colon of Hirschsprung's patients who underwent an operation and from patients operated on for tumors of the sigmoid colon and rectum, serving as controls. The changes in the contractile activity of the smooth-muscle strips after carbachol applied cumulatively were examined and dose-response curves were plotted. The EC50 values for the circular strips from the aganglionic part of the colon were 6 x 10(-7) M in Hirschsprung's patients and 3.

[Germ-cell tumors of the testis in childhood].

Germinative-cell tumors are the most common tumors of the testis in children. For a period of 15 years (1975-1989) the authors have observed 12 children with these tumors. Leading symptoms in all children was a gradual painless enlargement of one testis; the symptomatic hydrocele may delay the correct diagnosis for several months.

[Primary tumors of the stomach in childhood].

Two cases of primary tumors of the stomach in children (7 and 10 years of age) are reported. One of them had non-Hodgkin's lymphoma and the other hamartoma, both radically operated. In the former case subtotal resection of the stomach was made followed by polychemotherapy.

[Retroperitoneal and pelvic-presacral teratogenic tumors in early childhood--the diagnostic and surgical treatment problems].

Teratogenic tumors are characteristic for childhood. For a period of 15 years the authors have observed 12 children with retroperitoneal and pelvic-presacral localization of teratogenic tumors. They were most common in girls under one year of age.