Development and scale-up of rVSV-SARS-CoV-2 vaccine process using single use bioreactor.

The outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the Coronavirus Disease 2019 (COVID-19) has spread through the globe at an alarming speed. The disease has become a global pandemic affecting millions of people and created public health crises worldwide. Among many efforts to urgently develop a vaccine against this disease, we developed an industrial-scale closed, single use manufacturing process for V590, a vaccine candidate for SARS-CoV-2.

High-resolution laboratory reflectometer for the study of x-ray optical elements in the soft and extreme ultraviolet wavelength ranges.

A high-resolution laboratory reflectometer designed for operation in the soft x-ray (SXR) and extreme ultraviolet (EUV) ranges is described. High spectral resolution, up to 0.028 nm, in a wide spectral range is achieved due to the Czerny-Turner monochromator.

[A structural analysis of the behavior of cynomolgus macaques under the conditions of their group housing in cages].

The conceptual basis of the present study is an idea on systemic interdependence of neurobiological phenomena (at any level of their occurrence, including the integral behavioural level). Characteristic peculiarities of probable organization of natural behavioural activity of Java monkeys (M. irus) kept in cages in monosexual groups were studied by recording ethograms with subsequent computer analysis.

Normal-incidence multilayer mirrors for the 120-450 å wavelength region.

An electron-beam deposition method is used to fabricate spherical and flat mirrors with a peak reflectivity of 20% for wavelengths between 120 and 450 Å. It is experimentally shown that the fabricated mirrors can be employed to form an image with a resolution of 1 μm for ultrasoft x rays. The possibility of producing intense directional high-temperature plasma radiation by spherical multilayer mirrors is demonstrated.

[Individual typologic characteristics of the open-field behavior of rats].

By means of ethograms record and analysis, connection has been studied between the properties of rats behaviour organization in the open field, determining the level of behaviour entropy in this test, and the speed of conditioned reflexes formation in the Skinner chamber. According to behaviour entropy level the rats are significantly divided into four groups; the lowest speed of conditioned reflexes formation in the Skinner's chamber is observed in the animals of the first (low entropy) group, the highest--in the fourth (high entropy) group. The obtained data are discussed according to Pavlov's concepts on the characteristics of the basic nervous processes, determining individual-typological characteristics of the higher nervous activity of the animal.