Publications by authors named "I Iu Lebedeva"
Chronic hypereosinophilia, defined as persistent elevated blood levels of eosinophils ≥1,500/μL, is associated with tissue infiltration of eosinophils and consequent organ damage by eosinophil release of toxic mediators. The current therapies for chronic hypereosinophilia have limited success, require repetitive administration, and are associated with a variety of adverse effects. As a novel approach to treat chronic hypereosinophilia, we hypothesized that adeno-associated virus (AAV)-mediated delivery of an anti-human eosinophil antibody would provide one-time therapy that would mediate persistent suppression of blood eosinophil levels.
View Article and Find Full Text PDF[Transcranial magnetic stimulation (rTMS) in the treatment of depressive disorders].
Zh Nevrol Psikhiatr Im S S Korsakova
November 2024
Article Synopsis
- The study assessed the effectiveness and tolerance of two rTMS protocols in treating depression among 28 young patients.
- Results showed that 64.9% of patients responded positively to treatment, with similar outcomes regardless of the rTMS protocol used.
- Neurophysiological data suggested potential differences in how the two stimulation methods affect brain function, indicating a need for further research on their distinct mechanisms.
Structural and functional alterations in different types of delusions across schizophrenia spectrum: A systematic review.
Prog Neuropsychopharmacol Biol Psychiatry
October 2024
Article Synopsis
- The study investigates the relationship between different types of delusions in schizophrenia spectrum disorders and corresponding brain changes using a systematic review approach, following PRISMA guidelines.
- Researchers analyzed 1,752 records and included 95 relevant studies that utilized imaging techniques like fMRI and sMRI to identify structural and functional brain alterations linked to delusions.
- Key findings indicate that both specific and nonspecific delusions, particularly paranoia, are associated with changes in brain regions including the superior temporal cortex, anterior cingulate/medial prefrontal cortex, and insula.
A large body of research has shown that schizophrenia patients demonstrate increased brain structural aging. Although this process may be coupled with aberrant changes in intrinsic functional architecture of the brain, they remain understudied. We hypothesized that there are brain regions whose whole-brain functional connectivity at rest is differently associated with brain structural aging in schizophrenia patients compared to healthy controls.
View Article and Find Full Text PDFMany emerging applications, such as factory automation, electric power distribution, and intelligent transportation systems, require multicast Ultra-Reliable Low-Latency Communications (mURLLC). Since 3GPP Release 17, 5G systems natively support multicast functionality, including multicast Hybrid Automatic Repeat Request and various feedback schemes. Although these features can be promising for mURLLC, the specifications and existing studies fall short in offering guidance on their efficient usage.
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