Publications by authors named "I Iu Alimov"
The effects of severe plastic deformation on NiTi alloys' structure and properties have been extensively studied over the past decades. However, there is a notable lack of systematic data regarding the impact of industrial hot deformation techniques on these alloys. This gap arises from challenges in manufacturing processes related to the unevenness of ingots produced by casting technologies.
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- * Key factors like synthesis temperature, exposure time, and charge density were analyzed, revealing that temperatures above 1200 °C and exposure times longer than 12 hours are necessary for uniform β-phase formation.
- * The findings highlight the potential of this alloy for biocompatible implants and contribute to the understanding of metallothermic synthesis in materials science, benefiting professionals in powder metallurgy.
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- Bile acids play a crucial role in the gut by interacting with gut microbiota to regulate immune responses, although their exact physiological roles are not well understood.
- A new study identified two bile acid metabolites, 12-oxo-lithocholic acid (BAA485) and 11-oxo-12-hydroxylithocholic acid methyl ester (BAA473), which can activate the inflammasome, promoting the secretion of interleukin-18 (IL-18) in immune cells.
- The research suggests that these bile acid analogues may facilitate gut immune responses and could be important for understanding gut homeostasis and potential links to autoimmune diseases.
In an attempt to identify novel therapeutics and mechanisms to differentially kill tumor cells using phenotypic screening, we identified N-benzyl indole carbinols (N-BICs), synthetic analogs of the natural product indole-3-carbinol (I3C). To understand the mode of action for the molecules we employed Cancer Cell Line Encyclopedia viability profiling and correlative informatics analysis to identify and ultimately confirm the phase II metabolic enzyme sulfotransferase 1A1 (SULT1A1) as the essential factor for compound selectivity. Further studies demonstrate that SULT1A1 activates the N-BICs by rendering the compounds strong electrophiles which can alkylate cellular proteins and thereby induce cell death.
View Article and Find Full Text PDFHDAC inhibitors are promising antitumor drugs with several HDAC inhibitors already in clinical trials. LAQ824, a potent pan-HDAC inhibitor, has been shown to induce cell cycle arrest and cell death. However, the mechanism of its antitumor effects and specially its tumor selectivity are still poorly understood.
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