Publications by authors named "I Isordia-Salas"
ATR1 A1166C (rs5186), FII G20210A (rs1799963), FV G1691A (rs6025), FXIII 97G > T (rs11466016) and MTHFR A1298C (rs1801131) polymorphisms and the risk of ST-elevation myocardial infarction in young Mexican individuals.
Mol Biol Rep
January 2024
Article Synopsis
- A study investigated the link between specific genetic polymorphisms and ST elevation Myocardial Infarction in young Mexican individuals, involving 350 patients under 45 and 350 matched controls.
- The A1166C polymorphism was found to significantly increase the risk of Myocardial Infarction, while G20210A, G1691A, 97G > T, and A1298C did not show a similar association.
- Other factors like dyslipidemia, hypertension, smoking, and family history were also linked to increased risks, indicating that genetic variations might contribute to early cardiovascular issues, but more research is needed on gene interactions.
Genetic Variants Associated with High Susceptibility of Premature Ischemic Stroke.
J Renin Angiotensin Aldosterone Syst
December 2023
Background: Several polymorphisms had been associated with an increased risk of ischemic stroke, but results are inconclusive. The aim of this study was to examine the association between AGTR1 A1166C and TSP-1 N700S polymorphisms and ischemic stroke in a young Mexican population.
Methods: In a case-control study, 250 patients ≤ 45 years of age with ischemic stroke and 250 controls matched by age and gender were included.
Background: Essential hypertension is the result of modifiable and genetic factors, and it is associated with increased risk for atherothrombosis. Some polymorphisms are associated with hypertensive disease. The objective was to analyze the association between eNOS Glu298Asp, MTHR C677T, AGT M235T, AGT T174M, and A1166C and ACE I/D polymorphisms with essential hypertension in the Mexican population.
View Article and Find Full Text PDFBackground: Endothelial colony-forming cells (ECFCs) contribute to postnatal vasculogenesis. In venous thromboembolic disease (VTD), they are functionally abnormal and produce high concentrations of TNF-α.
Objective: To analyze the TNF-α signaling pathway and its relationship with the expression of cell-cycle regulators.
Background: Numerous polymorphisms in candidate genes coding for haemostatic system proteins have been proposed as risk factors for thrombosis.
Methods: We performed a case-control study of consecutive ischaemic stroke survivors aged ≤45 years, treated at our neurology department from 2006 to 2014. Polymerase chain reaction-restriction fragment length polymorphism identified the following polymorphisms: Thr325Ile and Ala147Thr in TAFI, 4G/5G in PAI-1, PLA1/A2 in platelet glycoprotein IIb/IIIa, Glu298Asp in eNOS, and C677T in 5,10-MTHFR.