Publications by authors named "I Ishikawa"
Background: Previous studies were examined effects of social restriction by COVID-19 pandemic on elderly peoples or compared difference of before/after restrictions on patients with Alzheimer disease-related dementia (ADRD). Here, we assessed the effects of restrictions on the cognitive function of the patients by comparing control group.
Methods: We examined the impact on cognitive function using the Alzheimer Disease Assessment Scale (Japanese version) cognitive subscale (ADAS-JCOG), in patients with mild to moderate ADRD by a post hoc subgroup analysis of double-blinded, noninferiority study of donepezil 27.
Background: Periodontal disease is characterized by chronic inflammation and destruction of supporting periodontal tissues, ultimately leading to tooth loss. In recent years, "cell-free treatment" without stem cell transplantation has attracted considerable attention for tissue regeneration. This study investigated the effects of extracts of mesenchymal stem cells (MSC-extract) and their protein components (MSC-protein) on the proliferation and migration of periodontal ligament (PDL) cells and whether MSC-protein can induce periodontal regeneration.
View Article and Find Full Text PDFNo previous study has published magnetic resonance imaging (MRI) findings for a subglottic pleomorphic adenoma. Here, we describe the case of a 62-year-old man with a subglottic pleomorphic adenoma. Endoscopic findings revealed a smooth-surfaced tumor arising from the subglottic posterior wall.
View Article and Find Full Text PDFArticle Synopsis
- This study introduces a new sperm retrieval technique called micromapping testicular sperm extraction (MMTSE) for treating nonobstructive azoospermia (NOA), aimed at providing a less invasive and more effective approach than traditional microscopic testicular sperm extraction (mTESE).
- MMTSE involves dividing the testis into four sections and making small needle holes to extract tubules, while allowing for real-time assessment of tissue for sperm presence.
- Results showed that all 15 patients in the sperm-positive group retrieved sperm successfully, while only 4 out of 25 in the sperm-negative group were successful with mTESE, highlighting MMTSE's potential benefits.
Background: Oral formulations are not suitable for demented patients with dysphagia, those refuse to take tablets, or those with drug compliance problem. However, only oral formulations of donepezil hydrochloride are approved for the treatment of severe Alzheimer's disease in Japan.
Objective: To evaluate the safety, tolerability, and efficacy of long-term application of a 55.