Publications by authors named "I Impalli"
Global trends in antibiotic consumption during 2016-2023 and future projections through 2030.
Proc Natl Acad Sci U S A
December 2024
Antibiotic resistance is a global public health threat. Many factors contribute to this issue, with human antibiotic consumption being significant among them. Analyzing trends and patterns in consumption can aid in developing policies to mitigate the burden of antimicrobial resistance and global disparities in access to antibiotics.
View Article and Find Full Text PDFAntimicrobial resistance (AMR), in which microbes adapt to and resist current therapies, is a well-recognised global problem that threatens to reverse gains made by modern medicine in the last decades. AMR is a complex issue; however, at its core, it is driven by the overuse and inappropriate use of antimicrobials. Socioeconomic factors have been identified as significant contributors to the emergence and exacerbation of AMR, especially in populations facing inadequate access to healthcare, poor sanitation services and high morbidity and mortality rates.
View Article and Find Full Text PDFArticle Synopsis
- - The rise of antibiotic-resistant bacterial infections worldwide calls for a commitment to developing new antibiotics, vaccines, and diagnostics, highlighting the inadequacy of the current drug development model that relies on significant profits.
- - Public-private partnerships and publicly funded models are proposed to facilitate investment in antibiotics, making them more affordable and accessible, especially in low-income and middle-income countries.
- - Improving access to antibiotics also requires better diagnostic practices and the use of vaccines to prevent infections, with the upcoming UN General Assembly meeting in 2024 serving as a crucial platform to rethink research and development strategies.