Publications by authors named "I Igarashi"
Article Synopsis
- FLLL-32, a synthetic curcumin analog, effectively inhibits the activation of STAT3 and shows anticancer properties while also exhibiting potential antiparasitic activity against multiple pathogens.
- In experiments, FLLL-32 inhibited the growth of several parasites in a dose-dependent manner and demonstrated strong activity against Babesia microti, both in cell cultures and in mice models.
- The study confirms FLLL-32's ability to reduce parasitemia in infected mice and suggests its potential use in treating babesiosis, particularly in combination with other antibabesial drugs.
Article Synopsis
- The study investigated the anti-growth effects of leaves methanolic extract (MOL) on various parasites in both cultures and infected mice, utilizing liquid chromatography mass spectrometry (LC-MS) to identify active compounds.
- MOL demonstrated a dose-dependent inhibition of parasite growth, exhibiting efficacy levels indicated by IC values, with isoquercetin and rutin identified as the most abundant polyphenolic compounds in the extract.
- When combined with low doses of diminazene aceturate (DA), MOL significantly reduced parasite growth in infected mice, suggesting its potential as an effective herbal therapy against piroplasmosis, especially when paired with specific anti-parasitic drugs.
Histone post-translational modification is one of the most studied factors influencing epigenetic regulation of protozoan parasite gene expression, which is mediated by histone deacetylases (KDACs) and acetyltransferases (KATs). The present study investigated the role of resveratrol (RVT) as an activator of histone deacetylases in the control of various pathogenic Babesia sp. and Theileria equi , as well as infected mice using fluorescence assay.
View Article and Find Full Text PDFArticle Synopsis
- The study developed new truncated recombinant proteins from Babesia caballi to enhance the detection of the infection in horses.
- The combination of full-length rBC134 and truncated rBC48 showed the best diagnostic performance, indicated by higher optical density values in infected sera.
- This cocktail antigen proved reliable, detecting infections as early as four days post-infection and demonstrated effectiveness across serum samples from multiple endemic regions.
In the present study, the effect of a combination therapy consisting of diminazene aceturate (DA) and imidocarb dipropionate (ID) on the in vitro growth of several parasitic piroplasmids, and on Babesia microti in BALB/c mice was evaluated using a fluorescence-based SYBR Green I test. We evaluated the structural similarities between the regularly used antibabesial medications, DA and ID, and the recently found antibabesial drugs, pyronaridine tetraphosphate, atovaquone, and clofazimine, using atom pair fingerprints (APfp). The Chou-Talalay approach was used to determine the interactions between the two drugs.
View Article and Find Full Text PDF