Publications by authors named "I Iaccarino"
The development of a fatal, clonal, autonomously proliferating CD4-CD8- chimeric antigen receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after a patient received treatment with tisagenlecleucel for relapsed primary central nervous system lymphoma. The PTCL had a clonal T-cell receptor rearrangement, which was already detectable in the apheresis product for CAR T-cell manufacturing and 7 months earlier for autologous transplantation. Somatic and mutations in CD34+ stem cells and their progeny were detected in the PTCL, in the apheresis specimen that was obtained for CAR T-cell production, and in the autotransplant.
View Article and Find Full Text PDFArticle Synopsis
- SRY-related HMG-box gene 11 (SOX11) is overexpressed in certain types of lymphomas but absent in normal B cells, playing an oncogenic role in mantle cell lymphoma (MCL) while its role in Burkitt lymphoma (BL) is still unclear.
- In EBV-negative BL cases, SOX11 expression is linked to specific genetic changes, such as IG∷MYC translocations, indicating an alternative pathogenic mechanism compared to SOX11-negative tumors.
- Bladder cancer with SOX11 expression shows unique genetic mutations and a different cell behavior pattern, highlighting two subsets of EBV-negative BL cases based on SOX11 presence and suggesting SOX11's involvement in the early development
Article Synopsis
- * A comprehensive analysis of 97 BCP-LBL cases revealed a mutational profile closely resembling that of BCP-ALL, though with a higher frequency of mutations in epigenetic modifiers in BCP-LBL.
- * The study found that most molecular subtypes from BCP-ALL are also present in BCP-LBL, suggesting that next-generation sequencing can help identify genetic subtypes in BCP-LBL, potentially